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Publications

Urinary outcomes are significantly affected by nerve sparing quality during radical prostatectomy

By:
Contributors: Eric Hyndman, MD, PhD

Urology. 2013 Dec;82(6):1348-53. doi: 10.1016/j.urology.2013.06.067. Epub 2013 Oct 3.

Kaye DR1, Hyndman ME, Segal RL, Mettee LZ, Trock BJ, Feng Z, Su LM, Bivalacqua TJ, Pavlovich CP.

Abstract

OBJECTIVE:

To assess the effect of nerve sparing (NS) quality on self-reported patient urinary outcomes after radical prostatectomy.

METHODS:

A total of 102 preoperatively potent men underwent laparoscopic or robotic radical prostatectomy; NS was prospectively graded at surgery using a 0-4 scale/neurovascular bundle. Urinary functional outcomes were measured by validated Expanded Prostate Cancer Index Composite questionnaire at baseline and follow-up time points (1, 3, 6, 9, and 12 months) in 99 men who underwent various degrees of NS. Mixed linear regression was used to analyze the effect of NS quality and other clinical factors on urinary outcomes.

RESULTS:

Patients with at least 1 neurovascular bundle spared completely, along with its supportive tissues (NS grade 4/4), noted significantly improved Expanded Prostate Cancer Index Composite urinary functional and continence outcomes as early as 1 month postoperatively and up to 12 months. Significantly less urinary bother was also noted in these men by 9-12 months postoperatively. Multivariate analysis revealed that bilateral or unilateral excellent NS (at least 1 bundle graded 4/4), increasing time from surgery, young patient age, and lower body mass index positively and significantly affected urinary functional outcomes, including pad use. Men who received excellent unilateral NS recovered urinary function about as well as men who had both neurovascular bundles spared in similar fashion.

CONCLUSION:

The quality of NS significantly influences patient-defined urinary functional convalescence. Completely sparing at least 1 neurovascular bundle along with its supportive tissues has a dramatic effect on the recovery of urinary continence and quality of life in preoperatively potent men.

 

PubMed

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Kaye Fund Awards: Congratulations to our APCaRI members!

University Hospital Foundation – Kaye Fund Awards

Congratulations to two APCaRI principal investigators; Dr. John Lewis and Dr. Frank Wuest for their 2018 Kaye Fund Awards! From an initial field of 80 applicants, 7 Kaye Fund Awards in total were given to medical researchers studying a diverse array of health-relevant topics of huge importance to Albertans and the rest of the world alike.

John Lewis’ project is titled “Improving the Management of Prostate Cancer Using Advanced Biofluid Diagnostics” and Frank Wuest’s project is “Novel Radiolabeled PSMA Inhibitors for Clinical PET Imaging of Prostate Cancer”. Both projects are poised to greatly improve prostate cancer diagnosis and treatment in the near future.

The University of Alberta Hospital (UAH), Kaye Edmonton Clinic (KEC) and the University Hospital Foundation (UHF) launched the Kaye Fund Competition in the fall of 2017. Recipients of this inaugural competition were announced July 4th, 2018. The Kaye Fund Competition aims to support individuals or collaborative, inter-disciplinary and multi-disciplinary teams in the pursuit of research, innovation and quality improvement projects that will establish new approaches to patient care.

The Kaye Fund Award is funded by a transformational $30 million donation from Mr. Donald Kaye. This gift is directed to advancing patient care and medical research to the Kaye Edmonton Clinic, and remains one of largest donations in the history of Canadian healthcare philanthropy.

Mr. Donald Kaye

Through his naming gift to the University Hospital Foundation, Donald Kaye has transformed years of hard work, prudent decision-making and wise investing into one of the largest donations in the history of Canadian healthcare philanthropy. And in doing so, Mr. Kaye is advancing patient care and medical research in a way that is both intently focused, and broadly based.  

 

 

- Perrin Beatty