Publications

Publications

Tumor vascular responses to antivascular and antiangiogenic strategies: looking for suitable models

By:
Contributors: Jihane Mriouah, PhD
Trends Biotechnol. 2012 Dec;30(12):649-58. doi: 10.1016/j.tibtech.2012.08.006. Epub 2012 Sep 26.

Abstract

Antiangiogenic and vascular disrupting agents are in the current cancer therapeutic armamentarium. A better understanding of the intricate mechanisms ruling neovessel survival within tumors during or after treatment is needed. Refinement of imaging and a growing knowledge of molecular biology of tumor vascularization provide new insights. It is necessary to define suitable methods for monitoring tumor response and appropriate tools to analyze data. This review compares most commonly used preclinical models, considering their recent improvements, and describes promising new approaches such as microfluidics, real-time electrical impedance based technique and noninvasive imaging techniques. The advantages and limitations of the in vitro, ex vivo and in vivo models are discussed. This review also provides a critical summary of emerging approaches using mathematical modeling.

 PubMed

Download PDF

Stay Informed

To stay up to date on all the latest news and publications, subscribe to our newsletter!

Time for the 2019 APCaRI Spring Symposium

It’s spring, time for APCaRI members to meet! Please register, using this link, to attend the 2019 APCaRI Spring Symposium. If you have any questions about the symposium please contact Rume.
See you soon!
Date: Saturday, May 11, 2019
Venue: Radisson Red Deer Hotel; 6500 67 St, Red Deer, AB T4P 1A2
Time: 8:30am – 4:00pm
Agenda – 2019 Spring Meeting

- Unknown