Publications

Publications

Tumor vascular responses to antivascular and antiangiogenic strategies: looking for suitable models

By:
Contributors: Jihane Mriouah, PhD
Trends Biotechnol. 2012 Dec;30(12):649-58. doi: 10.1016/j.tibtech.2012.08.006. Epub 2012 Sep 26.

Abstract

Antiangiogenic and vascular disrupting agents are in the current cancer therapeutic armamentarium. A better understanding of the intricate mechanisms ruling neovessel survival within tumors during or after treatment is needed. Refinement of imaging and a growing knowledge of molecular biology of tumor vascularization provide new insights. It is necessary to define suitable methods for monitoring tumor response and appropriate tools to analyze data. This review compares most commonly used preclinical models, considering their recent improvements, and describes promising new approaches such as microfluidics, real-time electrical impedance based technique and noninvasive imaging techniques. The advantages and limitations of the in vitro, ex vivo and in vivo models are discussed. This review also provides a critical summary of emerging approaches using mathematical modeling.

 PubMed

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Post-Doctoral Fellow Dr. Lian Willetts shines light on the frontiers of discovery

Dr. Lian Willetts was awarded 2nd place in the Falling Walls Lab Finale in Berlin representing Dr. John Lewis’ lab by presenting: “Breaking the Walls of Prostate Cancer Metastasis”

Lab Falling Walls is an international competition that challenges graduate students to showcase how their research is redefining their respective fields and breaking down the walls to the next major scientific breakthrough. The University of Alberta is one of 20 approved international events, and the Sept. 30 event saw 16 outstanding examples of graduate research. Dr. Willetts was awarded 1st place during this night.

International Labs and the Finale in Berlin

Falling Walls Lab is a global scale event that takes place in different vibrant cities around the world throughout the year. The Falling Walls Lab Finale is held each year in Berlin on 8 November. The Finale gathers 100 participants, among them all winners of the international Labs.

- Catalina Vasquez