Publications

Publications

Tumor vascular responses to antivascular and antiangiogenic strategies: looking for suitable models

By:
Contributors: Jihane Mriouah, PhD
Trends Biotechnol. 2012 Dec;30(12):649-58. doi: 10.1016/j.tibtech.2012.08.006. Epub 2012 Sep 26.

Abstract

Antiangiogenic and vascular disrupting agents are in the current cancer therapeutic armamentarium. A better understanding of the intricate mechanisms ruling neovessel survival within tumors during or after treatment is needed. Refinement of imaging and a growing knowledge of molecular biology of tumor vascularization provide new insights. It is necessary to define suitable methods for monitoring tumor response and appropriate tools to analyze data. This review compares most commonly used preclinical models, considering their recent improvements, and describes promising new approaches such as microfluidics, real-time electrical impedance based technique and noninvasive imaging techniques. The advantages and limitations of the in vitro, ex vivo and in vivo models are discussed. This review also provides a critical summary of emerging approaches using mathematical modeling.

 PubMed

Download PDF

Stay Informed

To stay up to date on all the latest news and publications, subscribe to our newsletter!

September is Prostate Cancer Awareness Month

September is not just for back to school its also to bring awareness to prostate cancer; how it affects men and their families, how it is diagnosed and treated currently, exciting new research into new diagnostic tools and therapies and how we can fundraise to help develop advances in care.

Check out Prostate Cancer Canada’s website that has lots of information about prostate cancer and what you can do to raise the awareness of this disease:

Get Involved in an event in your community!


					
- Perrin Beatty