Publications

Small cell-like glandular proliferation of prostate: A rare lesion not related to small cell prostate cancer

Virchows Arch. 2017 Jan;470(1):47-54

Kryvenko ON, Williamson SR, Trpkov K, Gupta NS, Athanazio D, Selig MK, Smith PT, Magi-Galluzzi C, Jorda M

Abstract

Small cell-like change (SCLC) is a rare prostate lesion which has been described in only two previous studies (total of eight cases). Its relation to possible neuroendocrine differentiation remained unclear. We evaluated 11 SCLC cases with immunohistochemistry and electron microscopy. SCLC was characterized by crowded hyperchromatic small nuclei with scant cytoplasm, rosette-like structures, finely granular chromatin with indistinct nucleoli, and lack of mitoses, apoptoses, and necroses. In nine cases, SCLC was admixed with high-grade cancer, and in two cases, it represented a separate intraductal process, spatially remote from a low-volume Gleason score 6 (grade group 1) cancer. Only 2/11 SCLC labeled for synaptophysin, chromogranin, and serotonin, although 6/11 were at least focally positive for TTF1. Staining for NKX3.1 and pancytokeratin was typically weak, focal, and markedly reduced compared to the adjacent cancer. SCLC was positive for ERG in 1/8 and for racemase in 6/10 cases, again typically in a focal and weak fashion. There was no immunoreactivity with CD56, p63, or HMWCK. Ki-67 highlighted only rare nuclei (<1 %). No neuroendocrine granules were demonstrated by electron microscopy in four cases that showed no immunoreactivity for neuroendocrine markers. In summary, SCLC is more frequently found in high-grade prostate cancer, but it may also be encountered as a noninvasive lesion in Gleason score 6 (grade group 1) cancer. Importantly, it does not appear to indicate neuroendocrine differentiation. The low-grade cytology, the lack of mitoses and apoptoses, and the minimal Ki-67 reactivity are findings to support its discrimination from a small cell carcinoma.

PubMed

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Congratulations to first place winner Doug Brown!

Congratulations to PhD grad student Doug Brown for his First Place win at the 2018 University of Alberta Student Falling Walls Lab Competition! Doug’s First Place award also gains him an entry and an all-expenses-paid trip to the highly competitive and prestigious Falling Walls Lab Conference in Berlin, November 8-9, 2018!

Fifteen student presenters pitched their innovative and globally-important research ideas in a short 3 minute presentation to a panel of science and tech-business savvy judges and a large cheering audience on September 19, 2018, at the University of Alberta in a high-stakes “TEDTalk” meets “Dragon’s Den” style. The competition was very strong but Doug gave an inspired speech on breaking down the walls of metastatic cancers using new lipid nanoparticle technology that he is helping to develop during his graduate studies in Dr. John Lewis’ laboratory.

The Sept 19th UofA Falling Walls Lab competition will be featured on Global News on the evening of Sept. 20th, around 6:15 pm. Check it out!

Doug will be taking his pitch to the Falling Walls Lab competition in Berlin, Germany this November where he will compete with many other inspirational students at this international event.

This is doubly exciting for the Lewis lab because John Lewis recently won the UofA Falling Walls Venture competition that was held on Aug 29, 2018 and he will be competing in the Berlin Falling Walls Venture!

Good luck to both Doug and John at the Falling Walls Finale in Berlin!

- Perrin Beatty