Multimodality Raman and photoacoustic imaging of surface-enhanced-Raman-scattering-targeted tumor cells
J Biomed Opt. 2016 Feb;21(2):20503.
Shi W, Paproski RJ, Shao P, Forbrich A, Lewis JD, Zemp RJ.
A multimodality Raman and photoacoustic imaging system is presented. This system has ultralow background and can detect tumor cells labeled with modified surface-enhanced-Raman-scattering (SERS) nanoparticles in vivo. Photoacoustic imaging provides microvascular context and can potentially be used to guide magnetic trapping of circulating tumor cells for SERS detection in animal models.