Publications

Publications

Detection of circulating tumor cells using targeted surface-enhanced Raman scattering nanoparticles and magnetic enrichment

By:
Contributors: Robert Paproski, PhD, Ronald Moore Research Group
J Biomed Opt. 2014 May;19(5):056014. doi: 10.1117/1.JBO.19.5.056014.

Abstract

While more than 90% of cancer deaths are due to metastases, our ability to detect circulating tumor cells (CTCs) is limited by low numbers of these cells in the blood and factors confounding specificity of detection. We propose a magnetic enrichment and detection technique for detecting CTCs with high specificity. We targeted both magnetic and surface-enhanced Raman scattering (SERS) nanoparticles to cancer cells. Only cells that are dual-labeled with both kinds of nanoparticles demonstrate an increasing SERS signal over time due to magnetic trapping.

PubMed

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APCaRI @ BIO2016

Members of APCaRI will be increasing awareness of the initiative and establishing collaborations to support high impact research by using biospecimens from the Alberta Prostate Cancer Biorepository.

More than 300 academic institutions, the world’s leading biotechs and top pharma companies can benefit from networking and educational opportunities at BIO2016.

- Catalina Vasquez