Publications

Publications

Automated radiosynthesis of no-carrier-added 4-[18F]fluoroiodobenzene: a versatile building block in 18F radiochemistry.

By:
Contributors: Frank Wuest Research Group
J Labelled Comp Radiopharm. 2014 Feb;57(2):104-9.

Abstract

4-[18F]Fluoroiodobenzene ([18F]FIB) is a versatile building block in 18F radiochemistry used in various transition metal-mediated C-C and C-N cross-coupling reactions and [18F]fluoroarylation reactions. Various synthesis routes have been described for the preparation of [18F]FIB. However, to date, no automated synthesis of [18F]FIB has been reported to allow access to larger amounts of [18F]FIB in high radiochemical and chemical purity. Herein, we describe an automated synthesis of no-carrier-added [18F]FIB on a GE TRACERlab™ FX automated synthesis unit starting from commercially available(4-iodophenyl)diphenylsulfonium triflate as the labelling precursor. [18F]FIB was prepared in high radiochemical yields of 89 ± 10% (decay-corrected, n = 7) within 60 min, including HPLC purification. The radiochemical purity exceeded 95%, and specific activity was greater than 40 GBq/μmol. Typically, from an experiment, 6.4 GBq of [18F]FIB could be obtained starting from 10.4 GBq of [18F]fluoride.

 

PubMed

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Together we are improving prostate cancer diagnostic and treatment options

We have an update on our moustaches for Movember (It’s Movember time to grow a mo for a bro!) and we coordinated our plaid (for Dad) at the same time! Hopefully, your Movember was as successful. APCaRI wants to send a thank you to Movember and Prostate Cancer Canada for their Men’s Health Awareness Drives. How else can we get our moustaches AND plaid on at the same time!
In the spirit of gratitude, APCaRI also recognizes our research staff for their hard work and dedication to improving prostate cancer care and future outcomes AND the nurses, oncologists, and urologists who work every day to help the men and their families touched by prostate cancer. Please know that your devotion to the patients and their treatment needs is greatly appreciated.

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