Publications

Publications

Automated radiosynthesis of no-carrier-added 4-[18F]fluoroiodobenzene: a versatile building block in 18F radiochemistry.

By:
Contributors: Frank Wuest Research Group
J Labelled Comp Radiopharm. 2014 Feb;57(2):104-9.

Abstract

4-[18F]Fluoroiodobenzene ([18F]FIB) is a versatile building block in 18F radiochemistry used in various transition metal-mediated C-C and C-N cross-coupling reactions and [18F]fluoroarylation reactions. Various synthesis routes have been described for the preparation of [18F]FIB. However, to date, no automated synthesis of [18F]FIB has been reported to allow access to larger amounts of [18F]FIB in high radiochemical and chemical purity. Herein, we describe an automated synthesis of no-carrier-added [18F]FIB on a GE TRACERlab™ FX automated synthesis unit starting from commercially available(4-iodophenyl)diphenylsulfonium triflate as the labelling precursor. [18F]FIB was prepared in high radiochemical yields of 89 ± 10% (decay-corrected, n = 7) within 60 min, including HPLC purification. The radiochemical purity exceeded 95%, and specific activity was greater than 40 GBq/μmol. Typically, from an experiment, 6.4 GBq of [18F]FIB could be obtained starting from 10.4 GBq of [18F]fluoride.

 

PubMed

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For years, Frank Sojonky hid his battle with prostate cancer from the world. But by 2004 he could hide it no longer, as the disease metastasized and began to spread. So when he learned from his oncologist, Dr. Peter Venner, that a chair in prostate cancer research was needed in Alberta, he made his personal goal to raise the funds to do it. That is how the Bird Dogs started and thanks to them and the Alberta Cancer Foundation, Dr. John Lewis and the Alberta Prostate Cancer Research Initiative are making important discoveries to improve the lives of those with prostate cancer.

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