Publications

Publications

Automated radiosynthesis of no-carrier-added 4-[18F]fluoroiodobenzene: a versatile building block in 18F radiochemistry.

By:
Contributors: Frank Wuest Research Group
J Labelled Comp Radiopharm. 2014 Feb;57(2):104-9.

Abstract

4-[18F]Fluoroiodobenzene ([18F]FIB) is a versatile building block in 18F radiochemistry used in various transition metal-mediated C-C and C-N cross-coupling reactions and [18F]fluoroarylation reactions. Various synthesis routes have been described for the preparation of [18F]FIB. However, to date, no automated synthesis of [18F]FIB has been reported to allow access to larger amounts of [18F]FIB in high radiochemical and chemical purity. Herein, we describe an automated synthesis of no-carrier-added [18F]FIB on a GE TRACERlab™ FX automated synthesis unit starting from commercially available(4-iodophenyl)diphenylsulfonium triflate as the labelling precursor. [18F]FIB was prepared in high radiochemical yields of 89 ± 10% (decay-corrected, n = 7) within 60 min, including HPLC purification. The radiochemical purity exceeded 95%, and specific activity was greater than 40 GBq/μmol. Typically, from an experiment, 6.4 GBq of [18F]FIB could be obtained starting from 10.4 GBq of [18F]fluoride.

 

PubMed

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APCaRI members participate in the 2016 CCI Golf Classic

Members of the APCaRI team felt very fortunate yesterday to participate in the Alberta Cancer Foundation’s 28th Annual Cross Cancer Institute Golf Classic – a wonderful event that has raised more than $12 million to pioneer revolutionary projects in support of patients at Alberta’s own Cross Cancer Institute and beyond.

Over the past 27 years, the Cross Cancer Institute Golf Classic has funded leading edge research, treatment and patient care programs at the Cross Cancer Institute. In 2016, the Alberta Cancer Foundation embarked on a new investment that will bring together the brightest minds in colorectal cancer research to increase survival rates and improve quality of life for colorectal patients across the province.

Heartfelt thanks to the amazing volunteers, the organizing committee, the Alberta Cancer Foundation, and all of the participants!

 

 

 

- Catalina Vasquez