Hans Vogel Research Group


Department of Biological Sciences, University of Calgary

BI 423
2500 University Dr. NW
Calgary, Alberta, Canada
T2N 1N4
Tel: 403-220-6006
e-mail: vogel@ucalgary.ca

Professor and AHFMR Scientist; Director BioNMR Centre, Metabolomics
University of Calgary, Calgary, AB

Dr. Vogel has been appointed as Full Professor of biochemistry at the University of Calgary since 1991, where he also directs the local bio-NMR centre. He has been the academic leader of the academic Metabolomics Research Centre since its inception in 2006.  His research interests include the application of protein chemistry and molecular biology methods, used in combination with high-resolution NMR spectroscopy. Using these methods, Dr. Vogel’s lab examines protein and peptide structures as well as their functional properties. They focus on several proteins, such as calcium-binding regulatory proteins, bacterial proteins mediating iron-uptake, and anti-microbial peptides.  Dr. Vogel has expertise in metabolic profiling biomarker discovery and has been involved many metabolomics studies in several areas such as infectious diseases and cancer.



Relevant Publications

Yamniuk, A.P., Gifford, J.L., Linse, S. and Vogel, H.J. (2008).  “The effects of metal binding loop       mutations on ligand-binding to the calcium- and integrin-binding protein 1:  Evolution of the EF-      hand?”  Biochemistry 47:1696-1707.

Andrushchenko, V.V., Aarabi, M.H., Nguyen, L.T., Prenner, E.J. and Vogel, H.J. (2008).        “Thermodynamics of the interactions of tryptophan-rich cathelicidin antimicrobial peptides with       model and natural membranes”.  Biochem. Biophys. Acta-Biomembranes 1778:1004-1014.

Shearer, J., Duggan, G., Weljie, A.M., Hittel, D.M., Wasserman, D. and Vogel, H.J. (2008).       “Metabolomic profiling of dietary-induced insulin resistance in the high fat fed C57BL/6J mouse”.        Diabetes, Obes. Metab. 10: 950-958.

Chan, D.I., Hunter, H.N., Tack, B.F. and Vogel, H.J. (2008).  “Human macrophage inflammatory       protein 3α:  solution structure, dimerization and anti-infective properties”.  Antimicrob. Agents       Chemother. 52:883-894.

Zulak, K.G., Weljie, A.M., Vogel, H.J. and Facchini, P.J. (2008).  “Quantitative 1H NMR       metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism       in elicitor-treated opium-poppy cell cultures”.  BMC Plant Biol. 8:5.

Ishida, H., Huang, H., Yamniuk, A.P., Takaya, Y. and Vogel, H.J. (2008).  “The solution       structures of two soybean calmodulin isoforms and their relationship to selective target-      activation properties.”  J. Biol. Chem. 283:14619-14628.

Ishida, H., Borman, M.A., Ostrander, J., Vogel, H.J. and MacDonald, J.A. (2008).  “Solution       structure of the calponin homology (CH)-domain from smoothelin-like 1 protein:  a unique apo-      calmodulin binding mode and the possible role of the C-terminal CH domain in smooth muscle       relaxation”.  J. Biol. Chem. 283:20569-20578.

Hagel, J.M., Weljie, A.M., Vogel, H.J. and Facchini, P.J. (2008).  “1H NMR metabolite profiling as a functional genomics platform to investigate alkaloid biosynthesis in opium poppy”.  Plant Physiol. 147: 1805-1821.

Haney, E.F., Nazmi, K., Lau, F., Bolscher, J.G.M. and Vogel, H.J. (2009).  “Novel lactoferrampin antimicrobial peptides derived from human lactoferrin”.  Biochimie 91: 141-154.

Pushie, M.J. and Vogel, H.J. (2008).  “Modeling by assembly and molecular dynamics of the low Cu2+ occupancy form of the mammalian prion protein octarepeat region:  gaining insight into Cu2+-mediated β -cleavage.”  Biophys. J. 95:5084-5091.

Chan, D.I., Stockner, T., Tieleman, D.P., and Vogel, H.J. (2008).  “Molecular dynamics simulations of apo-, holo- and acyl- forms of Escherichia coli acyl carrier protein.  J. Biol. Chem.  283:33620-33629.

Weljie, A.M., Newton, J., Jirik, F.R. and Vogel, H.J. (2008).  “Evaluating low-intensity unknown signals in quantitative proton NMR mixture analysis.”  Anal. Chem. 80: 8956-8965.

Yamniuk, A.P., Ishida, H., Lippert, D., and Vogel, H.J. (2009).  “Thermodynamic effects of non-coded and coded methionine-substitutions in calmodulin”. Biophys. J. 96: 1495-1507.

Pushie, M.J. and Vogel, H.J. (2009).  “A potential mechanism for Cu2+-reduction, β-cleavage and β-sheet initiation within the N-terminal domain of the prion protein:  Insights from density functional theory and molecular dynamics calculations”.  J. Toxicol. Environm. Health. 72: 1040-1059.

Lopez, C.S., Peacock, R.S., Crosa, J.H. and Vogel, H.J. (2009).  “Molecular characterization of TonB2 from the fish pathogen Vibrio anguilarum”.  Biochem J. 418: 49-59.

Wishart, D.S., Knox, C., 25 coauthors, Nazyrova, A, Shaykhutdinov, R, Li, L., Vogel, H.J. and Forsythe, I. (2009) “HMDB: a knowledgebase for the human metabolome.” Nucleic Acids Res. 37: D603-D610.

Haney, E.F., Hunter, H.N., Matsuzaki, K. and Vogel, H. J. (2009) “Solution NMR studies of amphibian antimicrobial peptides: linking structure to function?” Biochem. Biophys. Acta.  1778: 1639-1655.

Pushie, M.J., Rauk, A., Jirik, F. and Vogel, H.J. (2009) “Can copper binding to the prion protein generate a misfolded form of the protein?” Biometals 22: 159-175.

Dowlatabadi, R., Weljie, A.M., Thorpe, T.A., Yeung, E.C. and Vogel, H.J.  (2009).  “Metabolic footprinting study of white spruce embryogenesis using NMR spectroscopy”.  Plant Physiol. Biochem. 47: 343-350.

Yamniuk, A.P., Anderson, K.L., Fraser, M.E. and Vogel, H.J. (2009) “Auxiliary calcium-binding sites can influence the structure of CIB1” Protein Sci. 18:1128-1134.

Tremaroli V, Workentine ML, Weljie AM, Vogel HJ, Ceri H, Viti, C, Tatti E, Zhang P, Hyne  A, Turner RJ, Zannoni D. (2009) “Metabolomics investigation of bacterial response to metal challenge.” Appl. Environm. Microbiol. 75: 719-728.

Shaykhutdinov, R.A., MacInnis, G.D., Weljie, A.M. and Vogel, H.J.  (2009). “Quantitative analysis of metabolite concentrations in human urine samples using 13C{1H} NMR spectroscopy”.  Metabolomics 5: 307-317.

Krewulak, K. D., Koster, W. and Vogel, H.J. (2009).  “Siderophore-binding protein FhuD and related periplasmic proteins involved in bacterial iron uptake”.  Handbook of Metalloproteins, Wiley Press, Met. 251: 1-18.

Yamniuk, A.P., Burling, H. and Vogel, H.J. (2009).  “Thermodynamic characterization of the interactions between osteopontin and lactoferrin.” Mol. Immunol.  46: 2395-2402.

Ishida, H, Rainaldi, M. and Vogel, H.J. (2009) “Structural studies of soybean calmodulin isoform-4 complexed with MAPK-phosphatase-1 provides insight into a unique sequential target-binding mode.” J. Biol. Chem. 284: 28292-28305.

Llamas, M.A., vanderSar, A., Chu, B.C., Sparrius, M., Vogel, H.J. and Bitter, W. (2009) “A novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa”.  Plos Pathog. 5 (9): e1000572.

Lee, E.-J., Shaykhutdinov, R.A., Park, S.-U., Kim, Y.-K., Yang, T.-J., Weljie, A.M., Vogel, H.J., and Facchini, P.J.  (2009) “Quality assesment of ginseng by 1HNMR metabolite fingerprinting and profiling analysis.” J. Agric. Food Chem. 57: 7513-7522.

Nguyen L.T., Chan, D.I., Boszhard, L., Zaat, S.A.J. and Vogel, H.J. (2010) “Structures and antimicrobial activities of chemokine-derived carboxy-terminal helical peptides.” Biochem. Biophys. Acta-Biomembranes 1798: 1062-1072.

Huang, H., Ishida, H. and Vogel, H.J. (2010)  “The solution structure of the Mg2+ – form of soybean calmodulin isoforms reveals unique features of plant calmodulins in resting cells.”  Protein Sci. 19: 475-485.

Haney, E.F., Nathoo, S., Vogel, H.J. and Prenner, E.J.  (2010)  “Induction of non-lamellar lipid phases by antimicrobial peptides: a possible link to mode of action”.  Chem. Phys. Lipids. 163: 82-93.

Chan, D.I., Tieleman, D.P. and Vogel, H.J. (2010) “Molecular dynamics studies of beta-ketoacyl, beta-hydroxyacyl and trans-2-enoyl Acyl Carrier Protein of Escherichia coli”.  Biochemistry 49: 2860-2868.

Otten, R., Chu, B., Krewulak, K.D., Vogel, H.J. and Mulder, F.A.A. (2010) “Comprehensive and cost-effective NMR spectroscopy of methyl groups in large proteins”.  J. Am. Chem. Soc. 132: 2952-2960.

Workentine, M., Harrison, J., Weljie, A.M., Vogel, H.J., Ceri, H. and Turner, R.J. (2010) “Phenotypic and metabolic profiling of colony morphology variants evolved from Pseudomonas biofilms”.  Environment. Microbiol. 12: 1565-1577.

Nguyen, L.T., Chau, J.K., Perry, N.A., de Boer, L.,Zaat, S.A.J. and Vogel, H.J. (2010) “Serum stabilities and antimicrobial activities of short backbone-modified tryptophan- and arginine-rich peptides” PLoS One 5 (9): e12684.

White, A.P., Weljie, A.M., Apel, D., Zhang, P., Shaykhutdinov, R.A., Vogel, H.J. and Surette, M.G. (2010) “A global metabolic shift is linked to Salmonella multicellular development.” PLoS One 5 (7): e11814.

Ishida H. and Vogel, H.J. (2010) “The solution structure of a plant calmodulin and the CaM-binding domain of the vacuolar calcium-ATPase BCA1 reveals a new binding and activation mechanism.” J. Biol. Chem. 285: 38502-38510.

Chan, D.I. and Vogel, H.J. (2010) “Current understanding of fatty acid biosynthesis and the acyl carrier protein.” Biochem. J. 430: 1-19.

Chan, D.I., Chu, B.C., Lau, K.C., Hunter, H.N. Byers, D.M. and Vogel, H.J. (2010) “NMR solution structure and biophysical charcterization of Vibrio harveyi acyl carrier protein A75H; effects of divalent metal ions.”  J. Biol. Chem. 285: 30558-30566.

Ulke-Lemée, A., Ishida, H., Borman, M.A., Valderama, A., Vogel, H.J. and MacDonald, J.A. (2010) “Tropomyosin-binding properties of the chasm protein are dependent upon the calponin-homology domain.”  FEBS Lett. 584: 3311-3316.

Vogel, H.J. (2010) “Iron-uptake in Gram-negative bacteria and the battle for iron”  Bulletin of the Canadian Society for Biochemistry, Molecular and Cell Biology, 29-35.

Vogel, H.J. (2010) “Obituary: Dick van der Helm, an internationally recognized siderophore researcher and a crystallographer”  BioMetals 23: 597-599.

Chu, B.C., Garcia-Herrero, A., Johanson, T.H., Krewulak, K.D., Lau, C.K., Peacock, R.S., Slavinskaya, Z., and Vogel, H.J. (2010)  “Siderophore uptake in bacteria and the battle for iron with the host”  BioMetals 23: 601-611.

Krewulak, K.D. and Vogel, H.J. (2011)  “TonB or not TonB, is that the question?”  Biochem. Cell Biol. 89: 87-97.

Nguyen, L.T., Kwakman, P.H.S., Chan, D.I., de Boer, L., Zaat, S.A. and Vogel, H.J. (2011) “Profiling platelet antimicrobial chemokines: NMR backbone dynamics studies of the platelet chemokines NAP-2 and TC-1”  Antimicrob. Agents Chemother. 55: 2074-2083.

Duggan, G.E., Hittel, D.S., Tunnicliffe, J.M., Sensen, C.W., Weljie, A.M, Vogel, H.J. and Shearer, J.  (2011)  “Metabolic responsiveness to short term exercise training in lean and diet-induced insulin resistant mice” J. Appl. Physiol. 110: 1311-1318.

Chu, B.C. and Vogel, H.J. (2011)  “A structural and functional analysis of type III periplasmic and substrate binding proteins: their role in bacterial siderophore and heme transport”  Biol. Chem. 392: 39-52.

Schicho, R., Nazyrova, A., Shaykhutdinov, R., Duggan, G., Vogel, H.J. and Storr, M. (2010) “Quantitative metabolic profiling of serum and urine in DSS-induced ulcerative colitis of mice by 1H NMR spectroscopy”  J. Proteome Res. 7: 6265-6273.

Bathe, O.F., Shaykhutdinov, R.A., Kopciuck, K., Weljie, A.M., McKay, R., Sutherland, F., Dixon, E., Sotiropoulus, O., and Vogel, H.J. (2011)  “Feasibility of Identifying pancreatic cancer based on serum metabolomics”  Cancer Epidemiol. Biomarkers. Prev. 20: 140-147.

Duggan, G.E., Hittel, D.S., Vogel, H.J., and Shearer, J. (2011).  “Differentiating short- and long-term effects of diet in the obese mouse using 1H NMR metabolomics”  Diabetes Obes. Metab. 13: 859-862.

Duggan, G.E., Miller, J., Jirik, F.R., and Vogel, H.J. (2011)  “Metabolic profiling of vitamin C deficiency in Gulo-/-mice using NMR spectroscopy”  J. Biomol. NMR 49: 165-173.

Huang, H., Ishida, H., Yamniuk, A.P. and Vogel, H.J. (2011) “The solution structures of Ca2+-CIB1 and Mg2+-CIB1 and their interactions with the platelet integin alpha IIb cytoplasmic domain” J. Biol. Chem. 286: 17181-17192.

Gifford, J., Ishida, H. and Vogel, H.J. (2011)  “Fast methionine-based solution structure determination of calcium calmodulin complexes”  J. Biomol. NMR 50: 71-81.

Nguyen, L.T., de Boer, L., Zaat, S.A.J. and Vogel, H.J. (2011)  “Investigating the cationic side chains of the antimicrobial peptide tritipticin: hydrogen-bonding properties govern its membrane disruptive activities”  Biochem. Biophys. Acta-Biomembranes 1808: 2297-2303.

Chan, S.C., Haney, E.F., Vogel, H.J.   and Turner, R.J. (2011) “Towards understanding the Tat translocation mechanism through structural and biophysical studies of the amphipathic region of TatA from Escherichia coli” Biochem. Biophys. Acta 1808: 2289-2296.

Nguyen, L.T., Haney E. F. and Vogel, H.J. (2011) “The expanding scope of antimicrobial peptide structures and their modes of action”  Trends Biotechnol. 29: 464-472.

Saponja, J.A. and Vogel, H.J.  (2011)  “Quadrupolar central transition and carbon-13 NMR competition studies of metal ion binding to ovotransferrin”  Can. J. Chem. (special issue for Dr. Rod Wasylishen) 89: 779-788.

Nguyen, L.T., Chau, J.K., Zaat, S.A. and Vogel, H.J. (2011) “Cyclic tritrpticin analogs with distinct biological activities”  Probiotics Antimicrob Proteins 3: 132-143.

Bolscher, J.G.M., Oudhoff, M.J., Nazmi, J.M., Guimaraes, C.P., Haney, E.F., Garcia-Vallejo, J.J., Vogel, H.J., van‘t Hof, W., Ploegh, H.L. and Veerman, E.C. (2011)  “Sortase A as a tool for high yield histatin cyclization”  Faseb J. 25: 2650-2658.

Booth S.C., Workentine M.L., Wen J., Shaykhutdinov R., Vogel, H.J., Ceri H., Turner R.J., Weljie A.M. (2011)  “Differences in metabolism between the biofilm and planktonic response to metal stress”  J. Proteome Res. 10: 3190-3199.

Pushie, M.J., Shaykhutdinov, R., Nazyrova, A., Graham, A. and Vogel, H.J. (2011)  “Metabolomics study of chronic wasting disease biomarkers in elk serum”  J. Toxicol. Environm. Health A. 74: 1476-1492.

Kwakman P.H.S., Krijgsveld, J., de Boer, L., Nguyen, L.T., Boszhard, L., Vreede J., Dekker, H.L., Speijer, D., Drijfhout, J.W., te Velde, A.A., Crielaard, W., Vogel, H.J., Vandenbroucke-Grauls, C.M.J.E., Zaat, S.A.J. (2011)  “Native and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements”  J. Biol. Chem. 286: 43506-43514.

Hoerr, V. and Vogel, H.J. (2013)  “Metabolomics”  Encyclopedia of Biophysics, Springer (in press).

Rekdal, O., Haug, B.E., Kalaaji, M., Hunter, H.N., Lindin, I, Israelsson, I., Solstad, T., Yang, N., Brandt, M., Mantizilas, D. and Vogel, H.J. (2012)  “The relative spatial positions of tryptophans and cationic residues in helical membrane-active peptides determines their cytotoxicity”  J. Biol. Chem. 287: 233-244.

Haney, E.F., Nazmi, K., Bolscher, J.G.M. and Vogel, H.J. (2012) “Structural and biophysical characterization of an antimicrobial peptide chimera comprised of lactoferricin and lactoferrampin” Biochem. Biophys. Acta – Biomembranes 1818: 762-775.

Huang, H. and Vogel, H.J. (2012) “Structural basis for the activation of platelet integrin alphaIIb-beta3 by the calcium- and integrin-binding protein 1” J. Am. Chem. Soc. 134: 3864-3872.

Haney, E.F., Nazmi, K., Bolscher, J.G.M. and Vogel, H.J. (2012) “Influence of specific amino acid side-chains on the antimicrobial activity and structure of bovine lactoferrampin” Biochem. Cell Biol. 90: 362-377.

Vogel, H.J. (2012) “Lactoferrin, a bird’s eye view” Biochem. Cell Biol. 90: 233-244.

Liu, Z. and Vogel, H.J. (2012) “Molecular basis for the regulation of the N-terminal domain of the L-type voltage-gated calcium channel by calmodulin” Frontiers Molec. Neuroscience 5: 38 doi:10:3389/fnmol2012.00038

Bassagaya-Riera, J., Viladomiu, M., Pedragosa, M., De Simone, C., Carbo, A., Shaykhutdinov, R., Jobin, C., Arthur, J.C., Corl, B.A., Vogel, H.J.,Storr, M., Hontecillas, R. (2012) “Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPARgamma to suppress colitis” PLoS One 7(2): e31238.

Macdonald, J.A., Ishida, H., Butler, T.J., Ulke-Lemee, A., Chik, J. and Vogel, H.J. (2012) “The intrinsically disordered N-terminus of CHASM interacts with the calponin homology domain to provide an interface for tropomyosin binding”  Biochemistry 51: 2694-2705.

Huang, H., Bogstie, J.N., and Vogel, H.J. (2012) “Biophysical and structural studies of the human calcium- and integrin-binding protein family; comparing their functional properties” Biochem. Cell Biol. 90: 646-656.

Hoerr, V., Zbytnuik,, L., Leger,C., Tam, P., Kubes, P. and Vogel, H.J. (2012) ”Gram-negative and Gram-positive bacterial infections give rise to a different metabolic response in a mouse model” J. Proteome Res. 11: 3231-3245.

Schicho, R., Nazyrova, A., Shaykhutdinov, R., Vogel, H.J. and Storr, M. (2012) “Quantitative metabolomic profiling of serum, plasma and urine by 1H NMR spectroscopy discriminates between  patients with inflammatory bowel disease and healthy individuals”  J. Proteome Res. 11: 3344-3357.

Farshidhar, F., Weljie, A.M., Kopciuk, K., Buie, D., MacLean, A., Dixon, E., Sutherland, F.R., Molckovsky, A., Vogel, H.J. and Bathe, O.F. (2012). “Serum metabolomic profile as a means to distinguish stages of colorectal cancer” Genome Medicine 4 (5): 42.

Haney, E.F., Nguyen, L.T., Schibli, D.J. and Vogel, H.J. (2012) “Design of novel tryptophan-rich membrane-active antimicrobial peptides from the membrane-proximal region of the HIV glycoprotein gp41” Beilstein J. Org. Chem. 8: 1172-1184.

Gifford, J.L., Ishida, H. and Vogel, H.J. (2012) “Structural insights into calmodulin-regulated ectodomain shedding of L-selectin”  J. Biol. Chem. 287: 26513-26527.

Reimer, R.A., Maurer, A.D., Eller, R.K., Hallam, M.C., Shaykhutdinov, R., Vogel, H.J. and Weljie A.M. (2012) “Satiety hormone and metabolomic response to an intermittent high energy diet differs in rats consuming long term diets high in protein or prebiotic fibre” J.Proteome Res. 11: 4065-4074.

Nguyen L.T. and Vogel, H.J. (2012) “Structural perspectives on antimicrobial chemokines” Front. Immun. 3: 384. doi: 10.3389/fimmu.2012.00384

Vogel, H.J. (2012) Book Review of “Biological Inorganic Chemistry, a new introduction to molecular structure and function” by R.R. Crichton, 2nd edition, Elsevier Press., Coord. Chem. Rev. 256: 2760-2761.

Weininger, U., Liu, Z., McIntyre, D.D., Vogel, H.J. and Akke, M. (2012) “Specific 12CbD2-12CãD2-S-13CHD2 isotopomer labeling of methionine to characterize protein dynamics by 1H and 13C relaxation dispersion” J. Am. Chem. Soc. 134: 18562-18565.

Gifford, J.L., Jamshidiha, M. and Vogel, H.J.(2012) “ Probing proteins; calcium regulatory proteins” International Innovation (www.researchmedia.eu), Dec: 89-90.

Gifford, J.L., Ishida H. and Vogel, H.J. (2012)  “Structural characterization of the interaction of human lactoferrin with calmodulin” PLoS One 7(12): e51026. doi: 10.1371/journal.pone.0051026

Tørfoss, V., Isaksson, J., Ausbacher, D., Brandsdal, B., Flaten, G.E., Anderssen, T., Cavalcanti-Jacobsen, C., Havelkova, M., Nguyen, L.T., Vogel, H.J. and Strøm, M.B. (2012) “Improved anticancer potency by head-to-tail cyclization of short anticancer peptides containing a lipophilic beta2,2-amino acid”J. Pept. Sci. 18: 609-619.

Lau, C.K., Ishida, H., Liu, Z. and Vogel, H.J. (2013) “Solution structure of Escherichia coli FeoA and its potential role in bacterial ferrous iron transport” J. Bact. 195: 46-55.

Huang, H. and Vogel, H.J. (2013) “Purification and stable istope-labeling of calcium- and integrin-binding protein 1 for structural and functional NMR studies” Meth. Mol. Biol. (Ed. C. Heizmann), 963:99-113.

Mickiewicz, B., Vogel, H.J., Wong, H., Winston, B. (2013) “Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality” Am. J. Resp. Crit. Care Med. 187: 967-976. (see also the accompanying Editorial: “Metabolism, metabolome, and metabolomics in intensive care: is it time to move beyond monitoring of glucose and lactate?)

Arias, M., Zaat, S.A.J. and Vogel, H.J. (2013)  “Structure-function relationships of antimicrobial chemokines”  In: “Antimicrobial Peptides and Innate Immunity”.  Eds. P. Hiemstra and S.A.J. Zaat,  Springer, 183-218.

Ishida, H. and Vogel, H.J. (2013)  “EF-hand proteins”  Encyclopedia of Metalloproteins, Springer.

Gifford, J.L. and Vogel, H.J. (2013)  “EF-hand proteins and magnesium” Encyclopedia of Metalloproteins, Springer.

Haney, E.F., Petersen, A.P., Lau, C.K., Jing, W., Storey, D.G. and Vogel, H.J. (2013)  “Mechanism of action of puroindoline derived tryptophan-rich antimicrobial peptides” Biochim. Biophys. Acta – Biomembranes 1828: 1802-1813.

Schicho, R., Vogel, H.J., Storr, M. (2013) “Metabolomics: is it useful for inflammatory bowel diseases?”  Curr. Opin. Gastroenterol. 29: 378-383.

Palmnäs, M.S.A. and Vogel, H.J. (2013) “The future of NMR metabolomics in cancer therapy: towards personalizing treatment and developing targeted drugs?” Metabolites 3: 373-396.

Weininger, U., Blissing A.T., Hennig J., AhlnerA., LiuZ., VogelH.J., Akke M. and Lundström P. (2013) “Protein conformational exchange measured by 1H R1rho relaxation dispersion of methyl groups.” J. Biomol. NMR 57: 47-55.

Chu, B.C., Chan, D.I., deWolf, T., Periole, X. and VogelH.J. (2013) “Molecular dynamics simulations reveal that apo-HisJ can sample a closed conformation” Proteins (in press)

Chu, B.C., deWolf, T. and VogelH.J. (2013) “The role of the two structural domains from the periplasmic E.coli histidine binding protein HisJ” J. Biol. Chem. 288: 31409-31422.

Jamshidiha, M., Ishida, H., Gifford, J.L., Sutherland, C., Walsh, M.P. and Vogel, H.J. (2013) “Structural analysis of a calmodulin variant from rice: the C-terminal extension of OsCaM61 regulates its calcium binding and enzyme activation properties” J. Biol. Chem. 288: 32036-32049.

Gifford J.L., Jamsidiha, M., Mo, J., Ishida, H. and Vogel, H.J.  (2013) “Comparing the calcium-binding abilities of two soybean calmodulins: towards understanding the divergent nature of plant calmodulins” Plant Cell (in press)

Mickiewicz, B., Duggan, G.E., Winston, B., Doig, C., Kubes, P. and Vogel, H.J. (2013) “Metabolic profiling of serum samples by ¹H NMR spectroscopy as a potential diagnostic approach for septic shock” Crit. Care Med. (in press)


Saponja, J.A. and Vogel, H.J.  (2012)  “Carbon-13 NMR studies of the synergistic anion binding properties of ovotransferrin”  J. Biol. Inorg. Chem.

Krewulak, K., Bergmann, E.M. and Vogel, H.J. (2012)  “Site directed mutagenesis studies and the crystal structure of the apo-form of the siderophore binding protein FhuD reveal a potential mechanism for ferric-hydroxamate binding”  Biometals

Nekipelov, V., Liu, Z., McIntyre, D.D. and Vogel, H.J. (2012)  “NMR and microcalorimetry studies of monovalent cation binding to bovine α-lactalbumin”  Protein Sci.

Liu, Z., Garcia-Diaz, B., Catacchio, B., Chiancone, E. and Vogel, H.J. (2012) “The Pseudomonas aeruginosa inhibitor of vertebrate lysozyme exhibits a lower affinity for human lysozyme than its homolog from Escherichia coli”  PLoS One

Weljie, A.M., Walker, J.G., Baron, M., Eystathioy, T., Shaykhutdinov, R., Le Clercq, S., Fritzler, M. and Vogel, H.J. (2012) “Serum metabolite biomarkers of scleroderma elucidated with high resolution magnetic resonance spectroscopy”  Genome Medicine

Chau, J.K., Huebner, K., Shrive, N.G., Frank, C.B. and Vogel, H.J. (2012) “A characteristic plasma metabolic profile of an early degenerative joint disease rabbit model revealed by 1H NMR spectroscopy” Metabolomics

Easaw J., Singh A.D., Shaykhutdinov R., Wen J., Forsyth P., Vogel, H.J., Cairncross J.G., Weljie A.M. (2013) “Noninvasive brain tumor diagnosis and prognostication using metabolomics” Cancer Epidemiol. Biomarker Prev. (submitted).

Sarfarez O.M., Myers R.P., Coffin S.C., Gao Z.H., Shaheen A.A.M., Crotty P.M., Zhang P., Vogel, H.J.  Weljie A.M. (2013) “A metabolic profiling approach for the noninvasive assessment of liver histology in patients with chronic hepatitis C” Hepatology (submitted)

McConnell, Y.J., Weljie, A.M., Kopciuk, K.A., Dixon, E., Sutherland, F., Vogel, H.J. and Bathe, O.F. (2013) Serum metabolomic profile distinguished malignant versus bening pancreatic / periampullary lesions: combined use of 1H NMR and GC-MS. Cancer Epidemiol. Biomarker Prev. (submitted)

De Buck, J., Shaykhutdinov, R., Barkema, H. and Vogel, H.J. (2013) Metabolomics detects Mycobacterium avium subsp. Paratuberculosis infection in cattle in the early stages. J. Proteome Res. (submitted)

Chu, B.C., Otten, R., Mulder F.A.A. and Vogel, H.J.  (2013) “The solution structure, binding properties, and dynamics of the 34 kDa bacterial siderophore binding protein FepB” Molec. Microbiol. (revision)

Mickiewicz, B., Heard B.J., Chau J.K., Chung, M., Hart, D.A., Shrive N.G., Frank, C.B. and Vogel, H.J. (2013) “Metabolic profiling of synovial fluid in a unilateral ovine model of early degenerative changes in a knee joint” PLoS One (submitted)

Mickiewicz, B., Tam, P., Jenne, C.N., Leger, C., Wong, J., Winston, B.W., Doig, C., Kubes P. and Vogel, H.J. (2013) “Metabolomics and inflammatory mediator profiling as a prognostic approach for septic shock in the intensive care unit” Am. J. Resp. Crit. Care Med. (submitted)


Department of Biological Sciences, University of Calgary

BI 423
2500 University Dr. NW
Calgary, Alberta, Canada
T2N 1N4
Tel: 403-220-6006
e-mail: vogel@ucalgary.ca

Team Members

Ishrat Jalal
Marie Palmnas
Mauricio Arias
Mohammed Ilyas
Nusrat Shommu
Oluyemi Meduna
Subrata Paul