Pathologist, Associate Professor, Department of Laboratory Medicine and Pathology
University of Alberta, Cross Cancer Institute, Edmonton, AB
Dr Mengel is Interim Chair of the Department for Laboratory Medicine and Pathology at the University of Alberta, Edmonton, Canada. He is also Section Head for Transplantation Pathology at the Division of Anatomical Pathology. Outside his faculty Dr. Mengel is engaged in various international sub-specialty societies related to nephropathology and organ transplantation. He is the past Chair of the Transplant Diagnostics Community of Practice in the American Society of Transplantation, and a member of the Organizing Committee of the International Banff Conference for Allograft Pathology. He was Chair of the Program and of the Transplant Committee with the International Renal Pathology Society.
He studied medicine at the Semmelweiss University in Budapest, Hungary before going on to specialise in pathology and further in transplantation pathology and nephropathology. Before moving to Edmonton he was head of the transplant pathology service at the Hannover Medical School, Germany with responsibility for diagnostics and research based on transplant biopsies. In Edmonton, Dr. Mengel’s current work is focused on applying modern molecular and biostatistical techniques to biopsy specimens, with the aim to increase diagnostic precision in the area of organ transplanation.
Relevant Publications
D’Agati VD, Mengel M. 2013 The Rise of Renal Pathology in Nephrology: Structure Illuminates Function. Am J Kidney Dis Jun;61(6):1016-25.
Bröcker V, Mengel M. 2013 Histopathological diagnosis of acute and chronic rejection in pediatric kidney transplantation. Pediatr Nephrol, in press
Ozluk Y, Blanco PL, Mengel M, Solez K, Halloran PF, Sis B. 2012 Superiority of virtual microscopy versus light microscopy in transplantation pathology. Clin Transplant. Mar;26(2):336-44.
Mengel M, Husain S, Hidalgo L, Sis B. 2012 Phenotypes of antibody-mediated rejection in organ transplants. Transpl Int. Jun;25(6):611-22.
Ahmad Saliba K., Colak A., Gourishankar S. Mengel M. 2012 Images in Transplantation: Acute Renal Failure in a Kidney Donor. Am J Transplant. Volume 12, Issue 11, 2012, 3158–3160
Mengel M, Mihatsch M, Halloran P. 2011 Histological Characteristics of Calcineurin Inhibitor Toxicity-There Is No Such Thing as Specificity! Am J Transplant. Dec;11(12):2549-50
Poehnert D, Broecker V, Mengel M, Nashand B, Koch M. 2010 Induction of chronic renal allograft dysfunction in a rat model with complete and exclusive MHC incompatibility. Transpl Immunol. Feb;22(3-4):137-143
Hidalgo LG, Sellares J, Sis B, Mengel M, Chang J, Halloran PF. 2012 Interpreting NK Cell Transcripts Versus T-Cell Transcripts in Renal Transplant Biopsies. Am J Transplant. May;12(5):1180-91
M. Mengel, J. Reeve, S. Bunnag, G. Einecke, B. Sis, Th. Mueller, B. Kaplan, Ph.F. Halloran 2009 Molecular correlates of scarring in kidney transplants: the emergence of mast cell transcripts. Am J Transplant 9(1): 169-178.
Ghodsizad A, Niehaus M, Koegler G, Martin U, Wernet P, Bara C, Khaladj N, Loos A, Makoui M, Thiele J, Mengel M, Karck M, Klein HM, Haverich A, Ruhparwar A. 2009 Transplanted human cord blood derived unrestricted somatic stem cells improve left-ventricular function and prevent left-ventricular dilation and scar formation after acute myocardial infarction. Heart 25(1): 27-35.
Einecke G, Mengel M, Hidalgo L, Allanach K, Famulski KS, Halloran PF. 2009 The early course of kidney allograft rejection: defining the time when rejection begins. Am J Transplant 9(3): 483-493.
Bunnag S, Einecke G, Reeve J, Jhangri GS, Mueller TF, Sis B, Hidalgo LG, Mengel M, Kayser D, Kaplan B, Halloran PF. 2009 Molecular correlates of renal function in kidney transplant biopsies. J Am Soc Nephrol. 20(5):1149-60.
Reeve J, Einecke G, Mengel M, Sis B, Kayser N, Kaplan B, Halloran PF. 2009 Diagnosing Rejection in Renal Transplants: A Comparison of Molecular- and Histopathology-Based Approaches. Am J Transplant 9(8): 1802-1810
Mengel M, Reeve J, Bunnag S, Einecke G, Jhangri GS, Sis B, Famulski K, Guembes-Hidalgo L, Halloran PF. 2009 Scoring Total Inflammation Is Superior to the Current Banff Inflammation Score in Predicting Outcome and the Degree of Molecular Disturbance in Renal Allografts. Am J Transplant 9(8): 1859-1867
Skerka C, Licht C, Mengel M, Uzonyi B, Strobel S, Zipfel PF, Józsi M. 2009 Autoimmune forms of thrombotic micorangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles. Mol Immunol. Sep;46 (14):2801-7.
Hidalgo LG, Campbell PM, Sis B., Einecke G, Mengel M, Chang J, Halloran PF. 2009 De novo donor specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure. Am J Transplant; Nov;9(11):2532-41
Einecke G, Sis B., Reeve J, Mengel M, Campbell PM, Hidalgo LG, Halloran PF. 2009 Antibody mediated microcirculation injury is the major cause of late kidney transplant failure. Am J Transplant; Nov;9(11):2520-31
Sis B, Mengel M, M Haas, R Colvin, P Halloran, L Racusen, K Solez, W Baldwin, E Bracamonte, V Broecker, F Cosio, A Demetris, C Drachenberg, G Einecke, J Gloor, D Glotz, E Kraus, C Legendre, H Liapis, R Mannon, B Nankivell, V Nickeleit, J Papadimitriou, P Randhawa, H Regele, K Renaudin, E Rodriguez, D Seron, S Seshan, M Suthanthiran, B Wasowska, A Zachary, A Zeevi. 2010 Banff ’09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups. Am J Transplant. Mar;10(3):464-71
Sis B, Einecke G, Chang J, Hidalgo LG, Mengel M, Kaplan B Halloran PF. 2010 Cluster analysis of lesions in kidney transplant biopsies: Microcirculation changes, tubulointerstitial inflammation, and scarring. Am J Transplant. Feb;10(2):421-30
Famulski KS, Einecke G, Sis B, Mengel M, Hidalgo LG, Kaplan B, Halloran PF. 2010 Defining the Canonical Form of T-Cell-Mediated Rejection in Human Kidney Transplants. Am J Transplant. Apr;10(4):810-20
Ashton-Chess J, Le Mai H, Jovanovic V, Renaudin K, Foucher Y, Giral M, Moreau A, Dugast E, Mengel M, Racapé M, Danger R, Usal C, Smit H, Guillet M, Gwinner W, Le Berre L, Dantal J, Soulillou JP, Brouard S. 2010 Immunoproteasome beta subunit 10 is increased in chronic antibody-mediated rejection. Kidney Int. May;77(10):880-90
Einecke G, Reeve J, Sis B, Mengel M, Hidalgo L, Famulski K, Matas A, Kasiske B, Kaplan B, Halloran. 2010 A molecular classifier for predicting future graft loss in late human kidney transplant biopsies. J Clin Invest. Jun 1;120(6):1862-72
Hidalgo LG, Sis B, Sellares J, Campbell PM, Mengel M, Einecke G, Chang J, Halloran PF. 2010 NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection. Am J Transplant. Aug;10(8):1812-22.
Mengel M, Sis B, Kim D, Chang J, Famulski KS, Hidalgo LG, Einecke G, de Freitas D, Tymchak W, Burton J,Halloran PF. 2010 The molecular phenotype of heart transplant biopsies: Relationship to Histopathological and Clinical Variables. Am J Transplant. Sept;10(9):2105-15.
P. F. Halloran, D. G. De Freitas, G. Einecke, K. S. Famulski, L. G. Hidalgo, M. Mengel, J. Reeve, J. Sellares and B. Sis. 2010 Personal Viewpoint: An Integrated View of Molecular Changes, Histopathology and Outcomes in Kidney Transplants. Am J Transplant. Oct;10(10):2223-20
P. F. Halloran, D. G. De Freitas, G. Einecke, K. S. Famulski, L. G. Hidalgo, M. Mengel, J. Reeve, J. Sellares and B. Sis. 2010 Personal Viewpoint: The Molecular Phenotype of Kidney Transplants. Am J Transplant. Oct;10(10):2215-22
G. Einecke, D. Kayser, J. M. Vanslambrouck, B. Sis, J. Reeve, M. Mengel, K. S. Famulski, C. G. Bailey, J. E. J. Rasko and P. F. Halloran. 2010 Loss of Solute Carriers in T Cell-Mediated Rejection in Mouse and Human Kidneys: An Active Epithelial Injury–Repair Response Am J Transplant. Oct;10(10):2241–2251
D Jonigk, M Merk, K Hussein, L Maegel, K Theophile, M Muth, U Lehmann, C Bockmeyer, M Mengel, J Gottlieb, A Haverich, H Golpon, H Kreipe, F Laenger. 2011 Obliterative airway remodeling: molecular evidence for shared pathways in transplanted and native lungs. Am J Pathol. Feb;178(2):599-608
Sellarés J, de Freitas DG, Mengel M, Sis B, Hidalgo LG, Matas AJ, Kaplan B, Halloran PF. 2011 Inflammation lesions in kidney transplant biopsies: association with survival is due to the underlying diseases. Am J Transplant. Mar;11(3):489-99
M Mengel, J Chang, D Kayser, W Gwinner, A Schwarz, G Einecke, V Broecker, K Famulski, DG de Freitas, L Guembes-Hidalgo, B Sis, H Haller, PF Halloran. 2011 The molecular phenotype of six-week protocol biopsies from human renal allografts: Reflections of prior injury but not future course. Am J Transplant. Apr;11(4):708-18
Metzger J, Chatzikyrkou C, Broecker V, Schiffer E, Jaensch L, Iphoefer A, Mengel M, Mullen W, Mischak H, Haller H, Gwinner W. 2011 Diagnosis of subclinical and clinical acute T-cell-mediated rejection in renal transplant patients by urinary proteome analysis. Proteomics Clin Appl. Jun;5(5-6):322-33.
Erdbruegger U, Scheffner I, Mengel M, Schwarz A, Verhagen W, Haller H, Gwinner W. 2012 Impact of CMV infection on acute rejection and long-term renal allograft function: a systematic analysis in patients with protocol biopsies and indicated biopsies. Nephrol Dial Transplant. Jan; 27(1):435-43.
de Freitas D, Sellarés J, Mengel M, Chang J, Hidalgo L, Famulski K, Sis B, Einecke G, Halloran PF. 2012 The nature of biopsies with “Borderline Rejection” and prospects for eliminating this category. Am J Transplant. Jan; 12(1):191-201.
Sellarés J, de Freitas D, Mengel M, Reeve J, Einecke G,Sis B, Hidalgo L,Famulski K, Matas A, Halloran PF2012 Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and non-adherence. Am J Transplant. Feb; 12(2):388-99.
M Mengel, B Sis, M Haas, R.B. Colvin, P.F. Halloran, L.C. Racusen, K Solez, L Cendales, A.J. Demetris, C.B. Drachenberg, C. Farver, E.R Rodriguez, W.D Wallace, D Glotz. 2012 Banff 2012 Meeting Report: New Concepts in Antibody-Mediated Rejection. Am J Transplant. Mar;12(3):563-70.
Bröcker V, Schubert V, Scheffner I, Schwarz A, Hiss M, Becker JU, Scherer R, Haller H, Kreipe HH, Mengel M, Gwinner W. 2012 Arteriolar Lesions in Renal Transplant Biopsies: Prevalence, Progression, and Clinical Significance. Am J Pathol. May;180(5):1852-62.
Sis B, Jhangri G, Riopel J, Chang J, de Freitas D, Hidalgo L, Mengel M, Matas A, Halloran PF. 2012 A new scoring system and algorithm for antibody-mediated microcirculation inflammation in kidney transplants. Am J Transplant. May;12(5):1168-79.
Famulski KS, de Freitas DG, Kreepala C, Chang J, Sellares J, Sis B, Einecke G, Mengel M, Reeve J, Halloran PF. 2012 Molecular Phenotypes of Acute Kidney Injury in Kidney Transplants. J Am Soc Nephrol. 2012 May;23(5):948-58
Mueller-Deile J, Kümpers P, Achenbach J, Park JK, Mengel M, Haller H, Schiffer M. 2012 Podocalyxin-positive glomerular epithelial cells in urine correlate with a positive outcome in FSGS. J Nephrol, Sep;25(5):802-809.
Schiffer L, Schiffer M, Merkel S, Schwarz A, Mengel M, Jürgens C, Schroeder C, Zoerner AA, Püllmann K, Bröcker V, Becker JU, Dämmrich ME, Träder J, Großhennig A, Biertz F, Haller H, Koch A, Gwinner W. 2012 Rationale and design of the RIACT–study: a multi-center placebo controlled double blind study to test the efficacy of RItuximab in Acute Cellular tubulointerstitial rejection with B-cell infiltrates in renal Transplant patients: study protocol for a randomized controlled trial. Trials. Oct 26;13(1):199.
Mengel M, Campbell P, Gebel H, Randhawa P, Rodriguez ER, Colvin R, Conway J, Hachem R, Halloran P, Keshavjee S, Nickerson P, Murphey C, O’Leary J, Reeve J, Tinckam K, Reed EF. 2013 Precision Diagnostics in Transplantation: From Bench to Bedside. Am J Transplant Mar;13(3):562-8.
Reeve J, Sellarés J, Mengel M, Sis B, Skene A, Hidalgo L, de Freitas D, Famulski KS, Halloran PF. 2013 Molecular Diagnosis of T Cell-Mediated Rejection in Human Kidney Transplant Biopsies. Am J Transplant Mar;13(3):645-55.
Sellarés J, Reeve J, Loupy A, Mengel M, Sis B, Skene A, de Freitas D, Kreepala C, Hidalgo LG, Famulski KS, Halloran PF. 2013 Molecular Diagnosis of Antibody-Mediated Rejection in Human Kidney Transplants. Am J Transplant Apr;13(4):971-83.
Mengel M, Chan S, Climenhaga J, Kushner YB, Regele H, Colvin RB, Randhawa P. 2013 Banff Initiative for Quality Assurance in Transplantation (BIFQUIT): Reproducibility of C4d Immunohistochemistry in Kidney Allografts. Am J Transplant May;13(5):1235-45
Jeyakanthan M, Zhou X, Tao K, Mengel M, Rajotte RV, Larsen I, West LJ. 2013 Failure of Neonatal B-Cell Tolerance Induction by ABO-Incompatible Kidney Grafts in Piglets. Transplantation Sep;96(6):519-528
Hueper K, Rong S, Gutberlet M, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. 2013 T2 Relaxation Time and Apparent Diffusion Coefficient for Noninvasive Assessment of Renal Pathology After Acute Kidney Injury in Mice: Comparison With Histopathology. Invest Radiol., in press
Hueper K, Gutberlet M, Rong S, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F: 2013 Acute Kidney Injury: Arterial Spin Labeling to Monitor Renal Perfusion Impairment in Mice–Comparison with Histopathologic Results and Renal Function. Radiology, in press