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Prostate cancer ‘Rosetta stone’ paves way to new therapies

— almost 90% of metastatic prostate cancers have treatable defects —

A cancer genome sequencing study published last week in the prestigious journal Cell provides new and surprising information about metastatic prostate cancer that has become castration-resistant.

An international consortium of scientists pieced together the first comprehensive map of genetic mutations linked to metastatic prostate cancer from 150 patients and found that almost 90% of the men whose DNA they studied carried potentially treatable defects.

The findings suggest that these advanced cancers may be treated using a precision medicine approach, using a range of medicines that target specific gene mutations. Many of these medicines are already in use or undergoing clinical trials. They also learned that 8% of the men were born with genetic faults that predisposed them to prostate cancer, strengthening the case for screening people with a family history of the disease.

This research is groundbreaking because it provides solid evidence that there may be effective new treatment options for those with advanced prostate cancer who have become resistant to current therapies.

Click to read the original article abstract (you’ll need a subscription to read the entire manuscript).

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Prostate Cancer Canada’s Step Up Challenge 2019!

Prostate Cancer Canada’s Step Up Challenge 2019 pits endurance and drive against multistory office tower stairwells and gravity to raise funds for local prostate cancer research projects and initiatives in four Canadian cities. Heroic participants challenged the stairs in Toronto and Calgary on March 3rd, still to come is Vancouver on March 10th and Edmonton on March 17th (St. Patricks day!).

Congratulations to Calgary’s Step Up Challenge event participants who raised 111% of their $95 000 goal! These proceeds will support Dr. Tarek Bismar’s team at the University of Calgary. They are using blood samples from men with slow-growing prostate cancer that has not spread outside the prostate to determine if their disease is likely to advance. Learn more about this project from APCaRI and the Prostate cancer Collaborative Research Alliance.

Edmonton’s Step Up Challenge event is actively raising funds to support Dr. Kerry Courneya’s team at the University of Alberta, with 30% of the $65 000 goal reached currently. Dr. Courneya is a Professor and Canada Research Chair in Physical Activity and Cancer and Director of The Behavioral Medicine Laboratory and Fitness Center. This project is being led by doctoral student Dong-woo (Derek) Kang and will study whether exercise can reduce tumour growth and anxiety for men on active surveillance. Learn more about this project that could contribute to delaying, or even eliminating, the need for treatment from the Behavioral Medicine Laboratory and Fitness Center.

Dr. Kerry Courneya

ERASE-Scientific-Abstract

Please support the Edmonton Step Up Challenge 2019 as either a participant, or donor, or both!
The Lewis lab has entered Team Nanosteps into the challenge, check out our fundraising page and support the team by clicking on this link and making a secure online donation using your credit card.

Kerry Courneya’s Behavioral Medicine Lab team is also hitting the stairs, please click here to go to their Step Up Challenge team page to sponsor them with a donation as well!

Thanks in advance for any support you are able to provide. Get your runners and see you on March 17th!

- Perrin Beatty