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Prostate cancer ‘Rosetta stone’ paves way to new therapies

— almost 90% of metastatic prostate cancers have treatable defects —

A cancer genome sequencing study published last week in the prestigious journal Cell provides new and surprising information about metastatic prostate cancer that has become castration-resistant.

An international consortium of scientists pieced together the first comprehensive map of genetic mutations linked to metastatic prostate cancer from 150 patients and found that almost 90% of the men whose DNA they studied carried potentially treatable defects.

The findings suggest that these advanced cancers may be treated using a precision medicine approach, using a range of medicines that target specific gene mutations. Many of these medicines are already in use or undergoing clinical trials. They also learned that 8% of the men were born with genetic faults that predisposed them to prostate cancer, strengthening the case for screening people with a family history of the disease.

This research is groundbreaking because it provides solid evidence that there may be effective new treatment options for those with advanced prostate cancer who have become resistant to current therapies.

Click to read the original article abstract (you’ll need a subscription to read the entire manuscript).

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APCaRI 2019 Fall Symposium

APCaRI’s 13th symposium will take place at the Banff Park Lodge, in beautiful Banff, Alberta.
Please welcome our invited speaker, Dr. Andrew Vickers; Biostatistician and Research Methodologist from Memorial Sloan Kettering Cancer Center, New York, NY.
The APCaRI Fall Symposium is always an enriching and fun event! Attendees include clinicians, scientists, clinical research personnel, trainees, benefactors and representatives of prostate cancer support groups.
See you there!
Program – 2019 APCaRI Fall Symposium_Oct 25-26

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