Radiation Oncologist, Full Professor, Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, AB
Dr. Matthew Parliament is full Professor, Division of Radiation Oncology, Department of Oncology at the University of Alberta and Medical Director (interim) of the Cross Cancer Institute. The Division is active in all facets of cancer research, from basic discovery science, to pre-clinical studies, to translational science including biomarker discovery, and finally full scale human clinical trials. The academic oncology environment at the Cross Cancer Institute (an integrated stand-alone comprehensive cancer centre) ranks among the top oncology centres in Canada, and is consistently regarded highly from a national and international perspective for co-operative group clinical trial accrual and innovation.
His research expertise is in the domains of (1) state-of-art image-guided radiation therapy to improve cancer control and quality of life outcomes in cancer patients; (2) development and implementation of approaches to combine anatomic and functional imaging for patient prognostication, treatment targeting, and response assessment in oncology patients; and (3) studies of genomic and epigenetic approaches to bioprofiling of individuals undergoing radiation therapy to develop predictive algorithms for the risk of normal tissue late radiation toxicity (radiogenomics).
Relevant Publications
Michalski JM , Yan Y , Watkins-Bruner D , Bosch WR , Winter K , Galvin JM , Bahary JP , Morton GC , Parliament MB, Sandler HM, “Preliminary Toxicity Analysis of 3-Dimensional Conformal Radiation Therapy Versus Intensity Modulated Radiation Therapy on the High-Dose Arm of the Radiation Therapy Oncology Group 0126 Prostate Cancer Trial.”, International journal of radiation oncology, biology, physics PubMed ID: 24113055
Kerns SL , Stock RG , Stone NN , Blacksburg SR , Rath L , Vega A , Fachal L , Gómez-Caamaño A , De Ruysscher D , Lammering G, Parliament M, Blackshaw M , Sia M , Cesaretti J , Terk M , Hixson R , Rosenstein BS , Ostrer H, “Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer.”, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 107(3) PubMed ID: 23719583
Amanie J , Jans HS , Wuest M , Pervez N , Murtha A , Usmani N , Yee D, Pearcey R , Danielson B , Patel S , Macewan R , Field C , Robinson D , Wilson J , Lewis D , Parliament M , McEwan AJ, “Analysis of intraprostatic therapeutic effects in prostate cancer patients using [(11)C]-choline pet/ct after external beam radiation therapy.”, Current oncology (Toronto, Ont.), 20(2) PubMed ID: 23559873
Beesley R, Rieger J, Compton S, Parliament M, Seikaly H, Wolfaardt J, “Comparison of tooth loss between intensity-modulated and conventional radiotherapy in head and neck cancer patients.”, Journal of otolaryngology – head & neck surgery = Le Journal d’oto-rhino-laryngologie et de chirurgie cervico-faciale, 41(6) PubMed ID: 23700583
Andreassen CN, Dikomey E, Parliament M, West CM, “Will SNPs be useful predictors of normal tissue radiosensitivity in the future?”, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 105(3) PubMed ID: 23245645
Sahgal A, Roberge D, Schellenberg D, Purdie TG, Swaminath A, Pantarotto J, Filion E, Gabos Z, Butler J, Letourneau D, Masucci GL, Mulroy L, Bezjak A, Dawson LA, Parliament M, “The Canadian Association of Radiation Oncology scope of practice guidelines for lung, liver and spine stereotactic body radiotherapy.”, Clinical oncology (Royal College of Radiologists (Great Britain)), 24(9) PubMed ID: 22633542
Capelle L, Warkentin H, Mackenzie M, Joseph K, Gabos Z, Pervez N, Tankel K, Chafe S, Amanie J, Ghosh S, Parliament M, Abdulkarim B, “Skinsparing Helical Tomotherapy vs 3D-conformal Radiotherapy for Adjuvant Breast Radiotherapy: In Vivo Skin Dosimetry Study.”, International journal of radiation oncology, biology, physics, 83(5) PubMed ID: 22580119
Michalski J, Winter K, Roach M, Markoe A, Sandler HM, Ryu J, Parliament M, Purdy JA, Valicenti RK, Cox JD, “Clinical outcome of patients treated with 3D conformal radiation therapy (3D-CRT) for prostate cancer on RTOG 9406.”, International journal of radiation oncology, biology, physics, 83(3) PubMed ID: 22633552
Kubrak C, Olson K, Jha N, Scrimger R, Parliament M, McCargar L, Koski S, Baracos VE, “Clinical determinants of weight loss in patients receiving radiation and chemoirradiation for head and neck cancer: A prospective longitudinal view.”, Head & neck PubMed ID: 22730077
Pervez N, Krauze AV, Yee D, Parliament M, Mihai A, Ghosh S, Joseph K, Murtha A, Amanie J, Kamal M, Pearcey R, “Quality-of-life outcomes in high-risk prostate cancer patients treated with helical tomotherapy in a hypofractionated radiation schedule with long-term androgen suppression.”, Current oncology (Toronto, Ont.), 19(3) PubMed ID: 22670110
Schmidt KN, Olson K, Kubrak C, Parliament M, Ghosh S, “Validation of the Head and Neck Patient Symptom Checklist as a nutrition impact symptom assessment tool for head and neck cancer patients.”, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer PubMed ID: 22588710
Lam MC, Parliament M, Wong CK, “Argon plasma coagulation for the treatment of hemorrhagic radiation colitis.”, Case reports in gastroenterology, 6(2) PubMed ID: 22933988
Stuckless T, Milosevic M, de Metz C, Parliament M, Tompkins B, Brundage M, “Managing a national radiation oncologist workforce: a workforce planning model.”, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 103(1)
PubMed ID: 22296747
McNeely ML, Parliament MB, Seikaly H, Jha N, Magee DJ, Haykowsky MJ, Courneya KS, “Predictors of adherence to an exercise program for shoulder pain and dysfunction in head and neck cancer survivors.”, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 20(3) PubMed ID: 21347523
Robinson D, Liu D, Steciw S, Field C, Daly H, Saibishkumar EP, Fallone G, Parliament M, Amanie J, “An evaluation of the Clarity 3D ultrasound system for prostate localization.”, Journal of applied clinical medical physics / American College of Medical Physics, 13(4)
PubMed ID: 22766945
Parliament MB, “Radiogenomics: associations in all the wrong places?”, The lancet oncology, 13(1) PubMed ID: 22169270
Shakam A, Scrimger R, Liu D, Mohamed M, Parliament M, Field GC, El-Gayed A, Cadman P, Jha N, Warkentin H, Skarsgard D, Zhu Q, Ghosh S, “Dose-volume analysis of locoregional recurrences in head and neck IMRT, as determined by deformable registration: a prospective multi-institutional trial.”, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 99(2)
PubMed ID: 21621868
Parliament MB, Murray D, “Single nucleotide polymorphisms of DNA repair genes as predictors of radioresponse.”, Seminars in radiation oncology, 20(4) PubMed ID: 20832015
West C, Rosenstein BS, Alsner J, Azria D, Barnett G, Begg A, Bentzen S, Burnet N, Chang-Claude J, Chuang E, Coles C, De Ruyck K, De Ruysscher D, Dunning A, Elliott R, Fachal L, Hall J, Haustermans K, Herskind C, Hoelscher T, Imai, “Establishment of a Radiogenomics Consortium.”, International journal of radiation oncology, biology, physics, 76(5) PubMed ID: 20338472
Yee D, Parliament M, Rathee S, Ghosh S, Ko L, Murray B, “Cone beam CT imaging analysis of interfractional variations in bladder volume and position during radiotherapy for bladder cancer.”, International journal of radiation oncology, biology, physics, 76(4) PubMed ID: 19540057
Kubrak C, Olson K, Jha N, Jensen L, McCargar L, Seikaly H, Harris J, Scrimger R, Parliament M, Baracos VE, “Nutrition impact symptoms: key determinants of reduced dietary intake, weight loss, and reduced functional capacity of patients with head and neck cancer before treatment.”, Head & neck, 32(3) PubMed ID: 19626639
Bentzen SM, Parliament M, Deasy JO, Dicker A, Curran WJ, Williams JP, Rosenstein BS, “Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy: the importance of dose-volume effects.”, International journal of radiation oncology, biology, physics, 76(3 Suppl) PubMed ID: 20171510
Pervez N, Small C, MacKenzie M, Yee D, Parliament M, Ghosh S, Mihai A, Amanie J, Murtha A, Field C, Murray D, Fallone G, Pearcey R, “Acute toxicity in high-risk prostate cancer patients treated with androgen suppression and hypofractionated intensity-modulated radiotherapy.”, International journal of radiation oncology, biology, physics, 76(1) PubMed ID: 19395192
Michalski JM, Bae K, Roach M, Markoe AM, Sandler HM, Ryu J, Parliament MB, Straube W, Valicenti RK, Cox JD, “Long-term toxicity following 3D conformal radiation therapy for prostate cancer from the RTOG 9406 phase I/ II dose escalation study.”, International journal of radiation oncology, biology, physics, 76(1) PubMed ID: 19577865
Joseph KJ, Al-Mandhari Z, Pervez N, Parliament M, Wu J, Ghosh S, Tai P, Lian J, Levin W, “Reirradiation after radical radiation therapy: a survey of patterns of practice among Canadian radiation oncologists.”, International journal of radiation oncology, biology, physics, 72(5)
PubMed ID: 18501531
McNeely ML, Parliament MB, Seikaly H, Jha N, Magee DJ, Haykowsky MJ, Courneya KS, “Effect of exercise on upper extremity pain and dysfunction in head and neck cancer survivors: a randomized controlled trial.”, Cancer, 113(1) PubMed ID: 18457329
Saibishkumar EP, MacKenzie MA, Severin D, Mihai A, Hanson J, Daly H, Fallone G, Parliament MB , Abdulkarim BS, “Skin-sparing radiation using intensity-modulated radiotherapy after conservative surgery in early-stage breast cancer: a planning study.”, International journal of radiation oncology, biology, physics, 70(2) PubMed ID: 17881140
Saibishkumar EP, Jha N, Scrimger RA, MacKenzie MA, Daly H, Field C, Fallone G, Parliament MB, “Sparing the parotid glands and surgically transferred submandibular gland with helical tomotherapy in post-operative radiation of head and neck cancer: a planning study.”, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 85(1) PubMed ID: 17923162
Scrimger R, Kanji A, Parliament M, Warkentin H, Field C, Jha N, Hanson J, “Correlation between saliva production and quality of life measurements in head and neck cancer patients treated with intensity-modulated radiotherapy.”, American journal of clinical oncology, 30(3)
PubMed ID: 17551304
Damaraju S, Murray D, Dufour J, Carandang D, Myrehaug S, Fallone G, Field C, Greiner R, Hanson J, Cass CE, Parliament M, “Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.”, Clinical cancer research : an official journal of the American Association for Cancer Research, 12(8) PubMed ID: 16638864