Laboratory Technician, Dr. John Lewis Laboratory, Department of Oncology, University of Alberta
Deborah’s background is in Science and Biological Sciences Laboratory Research. After having a family member go through treatment for testicular cancer, she focused her career in cancer research. For 13 years, she was involved with the research and development of immunotheraputic vaccines mainly against Breast Cancer and Lung Cancer. Her expertise was MUC1 peptide-based liposome and microsphere formulations, nanoparticle vaccine delivery, and the evaluation of all vaccines in a murine model. She has had the privilege of working with University of Alberta Researchers Dr. Antoine (Tony) Noujaim, Dr. B. Michael Longenecker, and Dr. John Samuel, all associated with the development of cancer therapeutics as part of AltaRex Corp. and Biomira Inc. in Edmonton.
For the past 3 years, Deborah has been part of the APCaRI multi-disciplinary team involved with developing a new diagnostic test for Prostate Cancer. Her role is to screen samples from prostate cancer patients throughout Alberta, looking for novel biomarkers that are present at each stage of the disease progression. Once the biomarker profile is established, she will help develop a precise diagnostic test to be used in a clinical setting. With a new diagnostic test, it will be possible to track the current condition of the patient living with prostate cancer and initiate a treatment only when it is necessary to do so, thus improving their quality of life and outcome.
Christine M. E. Lutsiak, Deborah L. Sosnowski, David S. Wishart, Glen S. Kwon, and John Samuel. Use of Liposome Antigen Delivery System to Alter Immune Responses in Vivo. Journal of Pharmaceutical Sciences. 87 (11): 1428-1432. (1998).
Kimberly D. Newman, Deborah L. Sosnowski, Glen S. Kwon, and John Samuel. Delivery of MUC1 Mucin Peptide by Poly(d,l -lactic-co-glycolic acid) Microspheres Induces Type 1 T Helper Immune Responses. Journal of Pharmaceutical Sciences. 87 (11): 1421-1427. (1998).
Acknowledgements for technical support:
Daqing Wang, Ommoleila Molavi, M.E. Lutsiak, Praveen Elamanchili, Glen S. Kwon, and John Samuel. Poly(d,l lactic-co-glycolic acid) microsphere delivery of adenovirus for vaccination. Journal of Pharmaceutical Science 10 (2): 217-230, (2007).
Carrie S. Chong. Min Cao, Winnie W. Wong, Karl P. Fischer, William R. Addison, Glen S. Kwon, D. Lorne Tyrrell, and John Samuel. Enhancement of T helper type 1 immune response against hepatitis B core antigen by PLGA nanoparticle vaccine delivery. Journal of Controlled Release. 102, 85-99 (2005).
Daqing Wang, Deborah R. Robinson, Glen S. Kwon, and John Samuel. Encapsulation of plasmid DNA in biodegradable Poly(d,l lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. Journal of Controlled Release. 57, 9-18 (1999).
K. D. Newman, J. Samuel, and G. Kwon. Ovalbumin peptide in poly(d,l lactic-co-glycolic acid) microspheres is capable of inducing a T helper type 1 immune response. Journal of Controlled Release. 54, 49-59 (1998)
John Samuel, Wladyslaw A. Budzynski, Mark A. Reddish, Lei Ding, Gabrielle L. Zimmermann, Mark J. Krantz, R. Rao Koganty, and B. Michael Longenecker. Immunogenicity and antitumor activity of a liposomal MUC1 peptide-based vaccine. International Journal of Cancer. 75, 295-302 (1998).
Holly H. Guan, Wladyslaw Budzynski, R. Rao Koganty, Mark J. Krantz, Mark A. Reddish, James A. Rogers, B. Michael Longenecker, and John Samuel. Liposomal formulations of synthetic MUC1 peptides: effects of encapsulation versus surface display of peptides on immune responses. Bioconjugate Chemistry. 9, 451-458 (1998).
Jie Ma, John Samuel, Glen S. Kwon, Antoine A. Noujaim, Ragupathy Madiyalakan. Introduction of anti-idiotypic humoral and cellular responses by a murine monoclonal antibody recognizing the ovarian carcinoma antigen CA125 encapsulated in biodegradable microspheres. Cancer Immunology Immunotherapy. Chapter 29. (1998)
Holy H. Guan, Wladyslaw A. Budzynski, R. Rao Koganty, Mark J. Krantz, Mark A. Reddish, James A. Rogers, B. Michael Longenecker, and John Samuel. Liposomal formulations of synthetic MUC1 peptides: effects of encapsulation versus surface display of peptides on immune responses. Bioconjugate Chemistry. 9, 451-458 (1998).