Research Associate, Dr. Gane Wong Research Group,
Dr. Juan Jovel works as a research associate at the Department of Medicine of the University of Alberta, as part of Gane Wong’s group. His research focuses on application of OMICs and computational approaches to the study of human diseases, including prostate, liver and breast cancer, gastrointestinal diseases and viruses. At present, he is involved in projects concerning genomics and transcriptomics of metastatic prostate cancer determinants, the role of miRNAs on hepatocellular carcinoma, contribution of viruses to pre-terminal lymphoma, and perturbations of the gut microbiome in the context of breast cancer patients undergoing chemotherapy, or patients suffering ulcerative colitis, Crohn’s disease or Clostridium difficile infections, among other topics.
Wang W, Jovel J, Halloran B, Wine E, Patterson J, Ford G, O’keefe S, Meng B, Song D, Zhang Y, Tian Z, Wasilenko ST, Rahbari M, Reza S, Mitchell T, Jordan T, Carpenter E, Madsen K, Fedorak R, Dielemann LA, Wong G, Mason AL. 2015. Metagenomics analysis of microbiome in colon tissue from subjects with inflamatory bowel diseases reveals interplay of viruses and bacteria. Inflamm Bowel Dis. In press.
Perry T, Jovel J, Patterson J, Wong G, Fedorak RN, Thiesen A, Dicken B, Madsen KL. 2015. Fecal microbial transplant following ileocolic resection reduces ileitis but restores colitis in IL-10-/- mice. Inflamm Bowel Dis. In press.
Salim SY, Jovel J, Wine E, Kaplan GG, Vincent R, Thiesen A, Barkema HW, Madsen KL. 2014. Exposure to ingested airborne pollutant particulate matter increases mucosal exposure to bacteria and induces early onset of inflammation in neonatal IL-10 deficient mice. Inflamm Bowel Dis. 20(7):1129-38.
Law J*, Jovel J*, Patterson J, Ford G, O’keefe S, Wang W, Meng B, Song D, Zhang Y, Tian Z, Wasilenko S, Rabahri M, Mitchell T, Jordan T, Carpenter E, Mason A, Wong G. 2013. Identification of hepatotropic viruses from plasma using deep sequencing: a next generation diagnostic tool. PLoS One doi:10.1371/journal.pone.0060595. *First authors.
Han Y, Luo Y, Wu Q, Jovel J, Wang X, Aliyari R, Han C, Li WX, Ding, SW. 2011. RNA-based immunity terminates viral infection in adult Drosophila in absence of viral suppression of RNAi:Characterization of viral siRNA populations in wildtype and mutant flies. J. Virol. 85(24):13153-63.
Jovel J*, Schneemann A*. 2011. Molecular characterization of Drosophila cells persistently infected with Flock House virus.Virology 419(1):43-53. *Corresponding author.
Wang XB, Jovel, J, Udmporn P, Wang Y, Wu Q, Li, WX, Gasciolli V, Vaucheret H, Ding, SW. 2011. 21-nt, but not 22-nt, viral secondary siRNAs direct potent antiviral defense by two cooperative Argonautes in Arabidopsis thaliana. The Plant Cell 23:1625-1638.