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Detection of circulating tumor cells using targeted surface-enhanced Raman scattering nanoparticles and magnetic enrichment

By:
Contributors: Robert Paproski, PhD, Ronald Moore Research Group
J Biomed Opt. 2014 May;19(5):056014. doi: 10.1117/1.JBO.19.5.056014.
Shi W1, Paproski RJ1, Moore R2, Zemp R1.

Abstract

While more than 90% of cancer deaths are due to metastases, our ability to detect circulating tumor cells (CTCs) is limited by low numbers of these cells in the blood and factors confounding specificity of detection. We propose a magnetic enrichment and detection technique for detecting CTCs with high specificity. We targeted both magnetic and surface-enhanced Raman scattering (SERS) nanoparticles to cancer cells. Only cells that are dual-labeled with both kinds of nanoparticles demonstrate an increasing SERS signal over time due to magnetic trapping.

PubMed

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APCaRI is committed to collecting, processing and storing the samples you donate with the highest quality standards and as a result, after evaluation of our processes, the CTRNet (Canadian Tissue Repository Network) awarded us with their certification.

CTRNet is a translational cancer research resource, funded by Canadian Institutes of Health Research, that furthers Canadian health research by linking cancer researchers with provincial tumour banks.

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