Publications

Publications

Automated radiosynthesis of no-carrier-added 4-[18F]fluoroiodobenzene: a versatile building block in 18F radiochemistry.

By:
Contributors: Frank Wuest Research Group
J Labelled Comp Radiopharm. 2014 Feb;57(2):104-9.

Abstract

4-[18F]Fluoroiodobenzene ([18F]FIB) is a versatile building block in 18F radiochemistry used in various transition metal-mediated C-C and C-N cross-coupling reactions and [18F]fluoroarylation reactions. Various synthesis routes have been described for the preparation of [18F]FIB. However, to date, no automated synthesis of [18F]FIB has been reported to allow access to larger amounts of [18F]FIB in high radiochemical and chemical purity. Herein, we describe an automated synthesis of no-carrier-added [18F]FIB on a GE TRACERlab™ FX automated synthesis unit starting from commercially available(4-iodophenyl)diphenylsulfonium triflate as the labelling precursor. [18F]FIB was prepared in high radiochemical yields of 89 ± 10% (decay-corrected, n = 7) within 60 min, including HPLC purification. The radiochemical purity exceeded 95%, and specific activity was greater than 40 GBq/μmol. Typically, from an experiment, 6.4 GBq of [18F]FIB could be obtained starting from 10.4 GBq of [18F]fluoride.

 

PubMed

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APCaRI at the Enbridge Ride to Conquer Cancer for second year

Well, we did it again!  Several APCaRI members participated in a 2-day major cycling event called the Enbridge Ride to Conquer Cancer, benefiting the Alberta Cancer Foundation. We cycled 228 kms over 2 days along the majestic Rockies with thousands of other Riders, supported by an amazing team of volunteers. Riding along with over 50 members of the Cross Cancer Institute Team, and 1402 riders in total, it was an epic experience!
Most importantly, we raised $6.35M to support cutting edge cancer research in Alberta. We are very thankful for the support we received, which will help us to beat prostate cancer.

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