Laboratory Technician, Dr. John Lewis Laboratory, Department of Oncology, University of Alberta
Emma Woolner finished her B.Sc at The King’s University College in Edmonton in 2004 where she graduated with a Major in Biological Sciences and minored in Chemistry. Following her B.Sc, Emma obtained an M.Sc at the University of Alberta in the Department of Biochemistry studying the mechanism of inhibition of herpes simplex virus type 1 DNA replication by roscovitine. Her present research interests involve validation of novel biomarkers that can be used to predict prostate cancer metastasis. Recently her group completed the first whole human genome screen for novel genes that directly regulate metastatic spread of prostate cancer. To validate these results, they generated a panel of human and mouse cancer cell lines that are deficient for expression of these genes. Emma uses various molecular biology and biochemistry techniques to confirm genetic and functional knockdown of our target genes. Moreover, she evaluates whether knockdown of these particular proteins has an effect on the viability, proliferation rate, cancer-like growth, and potential to invade using wide range of in vitro models and techniques. Finally, she is involved in validation of these genes in prostate cancer metastasis using animal models developed by our group.